SummaryHofstenia miamia, commonly called the three-banded panther worm, is a small flatworm that can be found along the shores of the Caribbean and other warm waters. It is known for its impressive regenerative capabilities, including the ability to regenerate any body part within a few days of amputation. Previous reports identified some of the molecular signals used to coordinate regeneration (1), although the specific genes and gene networks that regulate this response were unknown. On page 1191 of this issue, Gehrke et al. (2) developed an impressive collection of genomic resources for the species, including extensive DNA, RNA, and chromatin accessibility data to promote H. miamia as a new model system for studying regeneration. Using these data, they identify early growth response (Egr), which encodes a candidate pioneer transcription factor responsible for regulating the molecular regenerating response to wounding.